Viagra (Sildenafil Citrate): Dosage and Side Effects

The world's top drug producing company, Pfizer pharmaceutical, is bringing revolution in the sex life of men bearing impotence through its miraculous drug Viagra introduced by it in 1998. The term impotence refers to the inability to erect one's penis. Although a number of other companies are also manufacturing similar drugs but Pfizer's Viagra has earned the reputation of being the doctor's first choice when it comes to impotence. A large number of men today are bearing the humiliation of impotence because of emotional disturbances and nutritional deficiencies. Viagra truly provides an escape from the frustration of impotence.

As soon as the person is sexually stimulated, his endothelial cells start making Nitric Oxide from an amino acid called L-arginine, with the help of an enzyme called Nitric Oxide synthase. The NO after being released from endothelial cells enters the blood vessels of lumen. In blood vessels, NO urges guanylyl cyclase, an enzyme, to break GTP into cGMP. cGMP acts a key to the golden lock of erection by causing dilation of vessels as result of which blood floods in the muscle of penis called corpus cavarnosum leading to erection. Impotent people are unable to fill their erectile muscle with sufficient blood required for erection. Viagra increases the blood inflow into the muscle of penis by raising the concentration of cGMP by halting an enzyme, phosphodiesterase , which splits cGMP into GMP. However one point to ponder here is that Viagra does not increase the production of cGMP, instead it raises its level by preventing its splitting from phosphodiesterase.

Viagra tablets are manufactured in different dosages that are 25mg, 50mg and 100mg. Beginners are usually started from 25mg dose. The dose is increased to 50mg once the user is habitual. 25mg dose is prescribed to older men. Care should be taken to not consume excessive amount because it causes hypotension which might prove lethal for health. The patients on Nitrate containing drugs are advised not to take Viagra because their combination might culminate in lowered blood pressure. Those who are taking Beta Blockers and Protease Inhibitors are also not prescribed Viagra because these drugs can interact with each other. Patients using Erythromycin are also not eligible for Viagra intake. Viagra commonly known as "blue pill" is taken 30 min before the act of sexual intercourse and its action lasts for about 4 hours. Sexual stimulation should be given for Viagra to perform its action.

Viagra consumers complain dizziness, headache, flushing, dyspepsia, diarrhea, hearing loss and visual disturbances. Another side effect sometimes faced is priapism. Priapism is a condition in which muscles of the penis undergo prolonged painful erection. These symptoms if encountered are supposed to disappear in some time but if these symptoms continue, users are advised to stop taking the drug and refer to their physician. Patients who have suffered from kidney disease or heart problems should consult doctor before starting Viagra. Physician should also be consulted first if you have once suffered from liver disease. Impotence is a hindrance between you and sexual pleasures you deserve. Viagra is a ladder to the sky of sexual pleasures.

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